Stealing VEGF from Thy Neighbor

Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration

Purpose This study addresses the hypothesis that age-related stresses upregulate Thy-1 in choroidal endothelial cells (CECs) and contribute to CEC activation and migration, processes important in choroidal neovascularization (CNV). Methods Measurements were made of Thy-1 protein (Western blot) in CECs and Thy-1 mRNA (real time quantitative PCR) in CECs treated with VEGF, CCL11, or PBS or in R...

Constrain-thy-neighbor effects as a determinant of transnational interest group cohesion

This article identifies conditions for transnational interest group cohesion by examining German and British employer positions on EU company law proposals. Employers were divided over proposals on takeover bids but formed a united front against proposals on worker participation. I argue that divergent “constrain-thy-neighbor effects” contribute to explaining the observed variation. Actors cons...

Antitrust in Open Economies

We examine antitrust rules in a two county general equilibrium trade model, contrasting national and multilateral (cooperative) determination of competition policy, exploring the properties of policy equilibrium. It is not imperfect competition, but variation in competitive stance between sectors that matters for trading partners. Beggar-thy-neighbor competition policies relate to countries’ co...

Don't love thy nearest neighbor

Early effects of intravitreal triamcinolone acetonide on inflammation and proliferation in human choroidal neovascularization.

OBJECTIVE To evaluate the early effects of triamcinolone acetonide (TA) on inflammation, proliferation, and vascular endothelial growth factor (VEGF) in human choroidal neovascularization (CNV). METHODS Retrospective review of an interventional case series of 29 patients who underwent macular translocation. Fourteen CNV membranes without previous therapy (control CNV group) and 4 CNV membrane...